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Safety and Tolerability of GLP-1, Dual, and Triple Agonists in Adolescents While GLP-1RAs and their dual and triple agonist counterparts have shown remarkable efficacy in weight loss and metabolic control, their safety and tolerability profiles remain key concerns, especially in adolescent populations

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This suggests that the model's predictions are sufficiently precise and reliable

In this predictive model, Salvia miltiorrhiza and Panax notoginseng showed high relevance, indicating their possible significance in ferroptosis regulation

Neuroinflammation also plays a major role, with microglial cells releasing inflammatory molecules such as TNF-, IL-6, and IL-1, along with ROS, all of which intensify neuronal damage (Liu and Wang, 2017)